Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics

  title={Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics},
  author={Oliver R{\"o}hrle and Utku S. Yavuz and Thomas Klotz and Francesco Negro and Thomas Heidlauf},
  journal={Wiley Interdisciplinary Reviews: Systems Biology and Medicine},
Mathematical models and computer simulations have the great potential to substantially increase our understanding of the biophysical behavior of the neuromuscular system. This, however, requires detailed multiscale, and multiphysics models. Once validated, such models allow systematic in silico investigations that are not necessarily feasible within experiments and, therefore, have the ability to provide valuable insights into the complex interrelations within the healthy system and for… 
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