Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics
@article{Rhrle2019MultiscaleMO, title={Multiscale modeling of the neuromuscular system: Coupling neurophysiology and skeletal muscle mechanics}, author={Oliver R{\"o}hrle and Utku S. Yavuz and Thomas Klotz and Francesco Negro and Thomas Heidlauf}, journal={Wiley Interdisciplinary Reviews: Systems Biology and Medicine}, year={2019}, volume={11} }
Mathematical models and computer simulations have the great potential to substantially increase our understanding of the biophysical behavior of the neuromuscular system. This, however, requires detailed multiscale, and multiphysics models. Once validated, such models allow systematic in silico investigations that are not necessarily feasible within experiments and, therefore, have the ability to provide valuable insights into the complex interrelations within the healthy system and for…
15 Citations
Modelling the electrical activity of skeletal muscle tissue using a multi-domain approach
- Biology, Computer ScienceBiomechanics and modeling in mechanobiology
- 2019
This work proposes a novel homogenised continuum model that closely resolves the electro-physiological behaviour of skeletal muscle tissue and shows the potential to employ the predicted virtual EMG signal in order to evaluate the goodness of automated decomposition algorithms.
A Physiology-Guided Classification of Active-Stress and Active-Strain Approaches for Continuum-Mechanical Modeling of Skeletal Muscle Tissue
- Biology, EngineeringFrontiers in Physiology
- 2021
This work provides an extensive discussion on the underlying modeling assumptions of both the active-stress and theactive-strain approach in the context of existing hypotheses of skeletal muscle physiology, and concludes that theActive-stress approach resolves an idealized tissue transmitting active stresses through an independent pathway.
Unifying system identification and biomechanical formulations for the estimation of muscle, tendon and joint stiffness during human movement
- Engineering, BiologyProgress in Biomedical Engineering
- 2021
A roadmap to achieve a unified framework for the estimation of time-varying stiffness in the composite human neuromusculoskeletal system during movement is presented and a novel combined closed-loop paradigm is proposed, in which reference estimates of joint stiffness via system identification are decomposed into underlying muscle and tendon contribution via high-density-electromyography-driven musculoskletal modeling.
Multiscale modeling of skeletal muscle to explore its passive mechanical properties and experiments verification.
- EngineeringMathematical biosciences and engineering : MBE
- 2022
The research of the mechanical properties of skeletal muscle has never stopped, whether in experimental tests or simulations of passive mechanical properties. To investigate the effect of…
Investigating the spatial resolution of EMG and MMG based on a systemic multi-scale model
- BiologyBiomechanics and modeling in mechanobiology
- 2022
A novel in silico model for EMG and MMG is proposed and the hypothesis that MMG surpasses EMG in terms of spatial selectivity is tested, i.e. the ability to distinguish spatially shifted sources.
Combining Ultrafast Ultrasound and High-Density EMG to Assess Local Electromechanical Muscle Dynamics: A Feasibility Study
- BiologyIEEE Access
- 2021
A novel non-invasive method to simultaneously track the propagation of both electrical and mechanical waves in muscles using high-density electromyography and ultrafast ultrasound imaging and can track the electromechanical muscle dynamics with high spatio-temporal resolution is proposed.
Quantitative and Qualitative Parameters of Myoelectric Signals for Computational Simulations of Human Surface Electromyograms
- Biology
- 2020
Results show that MUAPs obtained from Tibialis Anterior present greater values of P-P amplitude and durations than those from Triceps Surae muscles, and can be useful to confer some degree of biological realism to computational simulations of sEMG signals.
Estimation of the firing behaviour of a complete motoneuron pool by combining EMG signal decomposition and realistic motoneuron modelling
- BiologybioRxiv
- 2022
The proposed approach provides a validated tool for neuroscientists, experimentalists, and modelers to infer the firing activity of MNs that cannot be observed experimentally, investigate the neurophysiology of human MN pools, support future experimental investigations, and advance neuromuscular modelling for investigating the neural strategies controlling human voluntary contractions.
Variations in Muscle Activity and Exerted Torque During Temporary Blood Flow Restriction in Healthy Individuals
- EngineeringFrontiers in Bioengineering and Biotechnology
- 2021
The results show strong yet transitory effects of BFR that are compatible with a motor neuron pool inhibition caused by increased activity of type III and IV afferences, and a decreased activity of spindle afferents.
A leg to stand on: computational models of proprioception.
- Biology, PsychologyCurrent opinion in physiology
- 2021
References
SHOWING 1-10 OF 311 REFERENCES
An integrated model of the neuromuscular system
- Biology2013 6th International IEEE/EMBS Conference on Neural Engineering (NER)
- 2013
The integrated model allows the simulation of the entire pathway from supraspinal input to force production enabling the investigation of various phenomena of the neuromuscular system, and the analysis of different physiological hypotheses.
A Physiologically Based, Multi-Scale Model of Skeletal Muscle Structure and Function
- Biology, EngineeringFront. Physio.
- 2012
The conventional biophysically based modeling methodology is extended to include several structural and functional characteristics of skeletal muscle and the proposed framework provides a novel simulation-based way to investigate muscle behavior ranging from motor-unit recruitment to force generation and fatigue.
Chemo-electro-mechanical modelling of the neuromuscular system
- Chemistry
- 2015
Body movement is the result of cascades of complex chemical, electrical, and mechanical processes taking place at different length and time scales. This thesis deals with the biophysical modelling of…
Comprehensive biomechanical modeling and simulation of the upper body
- Biology, EngineeringTOGS
- 2009
A comprehensive biomechanical model of the human upper body and an associated physics-based animation controller that computes the muscle activation signals necessary to drive the elaborate musculoskeletal system in accordance with a sequence of target poses specified by an animator are introduced.
Multiscale Skeletal Muscle Modeling: From Cellular Level to a Multi-segment Skeletal Muscle Model of the Upper Limb
- Engineering, Biology
- 2013
Two skeletal muscle models are presented that are an electromechanical skeletal muscle model that couples neurophysiological recruitment principles and electrochemical processes of a sarcomere to the mechanical behavior of a single skeletal muscle through a multiscale continuum-mechanical constitutive law.
Mathematical models of proprioceptors. II. Structure and function of the Golgi tendon organ.
- BiologyJournal of neurophysiology
- 2006
A physiologically realistic mathematical model of the Golgi tendon organ whose elements correspond to anatomical features of the biological receptor is developed, consistent with the anatomy of the afferent innervation and its arrangement with respect to the collagen strands inserting into the GTO.
Micromechanical modelling of skeletal muscles based on the finite element method
- EngineeringComputer methods in biomechanics and biomedical engineering
- 2008
A new concept for the modelling of skeletal muscles is proposed that incorporates the behaviour of the smallest possible unit, the so-called sarcomere, also known as microbiological engine, at the level of the contractile muscle fibres.
In Vivo Neuromechanics: Decoding Causal Motor Neuron Behavior with Resulting Musculoskeletal Function
- Biology, PsychologyScientific Reports
- 2017
A new class of neural data-driven musculoskeletal modeling formulations for bridging between movement neural and mechanical levels in vivo with implications for understanding motor physiology, pathology, and recovery are provided.
A two-muscle, continuum-mechanical forward simulation of the upper limb
- EngineeringBiomechanics and modeling in mechanobiology
- 2017
A forward-dynamics simulation framework of a musculoskeletal system, in which all components are represented as continuous, three-dimensional, volumetric objects, which demonstrates that the proposed methods can be linked to state-of-the-art control algorithms predicting time-dependent muscle activation levels based on principles of forward dynamics.
Bridging Scales: A Three-Dimensional Electromechanical Finite Element Model of Skeletal Muscle
- BiologySIAM J. Sci. Comput.
- 2008
A framework for skeletal muscles that couples outputs from a detailed biophysically based electrophysiological cell model to a three-dimensional continuum-based finite element model of muscle mechanics to investigate the mechanical effects with respect to cellular changes or to analyze the effects of different neuromuscular activation patterns on the tissue response is introduced.