Multiscale mechanisms of cell migration during development: theory and experiment.

  title={Multiscale mechanisms of cell migration during development: theory and experiment.},
  author={Rebecca McLennan and Louise Dyson and Katherine W Prather and Jason A Morrison and Ruth E. Baker and Philip K. Maini and Paul M Kulesa},
  volume={139 16},
Long-distance cell migration is an important feature of embryonic development, adult morphogenesis and cancer, yet the mechanisms that drive subpopulations of cells to distinct targets are poorly understood. Here, we use the embryonic neural crest (NC) in tandem with theoretical studies to evaluate model mechanisms of long-distance cell migration. We find that a simple chemotaxis model is insufficient to explain our experimental data. Instead, model simulations predict that NC cell migration… CONTINUE READING
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