Multiscale Layered Biomechanical Model of the Pacinian Corpuscle

@article{Biswas2015MultiscaleLB,
  title={Multiscale Layered Biomechanical Model of the Pacinian Corpuscle},
  author={Abhijit Biswas and M. Manivannan and Mandayam A. Srinivasan},
  journal={IEEE Transactions on Haptics},
  year={2015},
  volume={8},
  pages={31-42}
}
This paper describes a multiscale analytical model of the lamellar structure and the biomechanical response of the Pacinian Corpuscle (PC). In order to analyze the contribution of the PC lamellar structure for detecting high-frequency vibrotactile (VT) stimuli covering 10 Hz to a few kHz, the model response is studied against trapezoidal and sinusoidal stimuli. The model identifies a few generalizable features of the lamellar structure which makes it scalable for different sizes of PC with… Expand
Computational Parametric Analysis of the Mechanical Response of Structurally Varying Pacinian Corpuscles.
TLDR
This study provides two simple expressions that can be used to predict the impact of structural or material changes with aging or disease on the frequency response of the PC. Expand
A multiphysics model of the Pacinian corpuscle.
TLDR
This work combines mechanical models of the PC with an electrochemical model of peripheral nerves to simulate the tactile response of the entire system, and supports the hypothesis that PC rapid adaptation is affected by the lamellar structures without requiring neuronal adaptivity. Expand
Multiscale Mechanical Model of the Pacinian Corpuscle Shows Depth and Anisotropy Contribute to the Receptor’s Characteristic Response to Indentation
TLDR
A multiscale finite-element model was used to model the equilibrium response of the Pacinian corpuscle, predicting decreased compressive strain with proximity to the receptor’s core, as seen experimentally by others. Expand
Micropipette aspiration of the Pacinian corpuscle.
TLDR
This study used micropipette aspiration to determine an apparent Young's modulus for PCs isolated from a cadaveric human hand, and estimated the PC to be on the same order of magnitude as skin or isolated cells, so it is recommended that a modulus in the kPa range be used in future studies. Expand
An inter-species computational analysis of vibrotactile sensitivity in Pacinian and Herbst corpuscles
TLDR
This work applied an earlier computational model of the Pacinian corpuscle to predict the sensory response of different species to various stimulus frequencies, and based on the results, identified the optimal frequency for vibration sensing and the bandwidth over which frequencies should be most detectable. Expand
Vibrotactile Sensitivity Threshold: Nonlinear Stochastic Mechanotransduction Model of the Pacinian Corpuscle
TLDR
A two-stage mechanotransduction model of its near threshold Vibrotactile (VT) sensitivity valid over 10 Hz to a few kHz is described and can be extended to simulate the neural response of a group of PCs. Expand
Printing a Pacinian Corpuscle: Modeling and Performance
TLDR
A scalable mechanical model of the Pacinian corpuscle is developed and uses the model to predict the response of synthetic corpuscles, which could be the basis for future vibration sensors. Expand
Computational Model of a Pacinian Corpuscle for an Electrical Stimulus: Spike-Rate and Threshold Characteristics
TLDR
A PC model with equivalent circuits of the electrode-skin interface, PC’s neurite, and the first Ranvier node is developed and can be extended to study the combination of electrical and mechanical stimuli. Expand
Multiscale modeling methods in biomechanics
TLDR
A review of papers targeting the musculoskeletal and the cardiovascular systems, and covered only a few exemplary papers targeting other organ systems, shows a research subdomain still in its infancy, where causal confirmation papers remain the most common. Expand
Layered patterns in nature, medicine, and materials: quantifying anisotropic structures and cyclicity
TLDR
A parameter disorder of layer structure (DStr) is presented to describe the deviation of a study object’s anisotropic structure from an isotropic analog and it is illustrated that charts and DStr could be used as local and global morphological characteristics describing various layered systems such as images of, for example, geological, atmospheric, medical, materials, forensic, plants, and animals. Expand
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