Multiscale Layered Biomechanical Model of the Pacinian Corpuscle

@article{Biswas2015MultiscaleLB,
  title={Multiscale Layered Biomechanical Model of the Pacinian Corpuscle},
  author={Abhijit Biswas and M. Manivannan and Mandayam A. Srinivasan},
  journal={IEEE Transactions on Haptics},
  year={2015},
  volume={8},
  pages={31-42}
}
This paper describes a multiscale analytical model of the lamellar structure and the biomechanical response of the Pacinian Corpuscle (PC). In order to analyze the contribution of the PC lamellar structure for detecting high-frequency vibrotactile (VT) stimuli covering 10 Hz to a few kHz, the model response is studied against trapezoidal and sinusoidal stimuli. The model identifies a few generalizable features of the lamellar structure which makes it scalable for different sizes of PC with… 

Figures and Tables from this paper

Computational Parametric Analysis of the Mechanical Response of Structurally Varying Pacinian Corpuscles.
TLDR
This study provides two simple expressions that can be used to predict the impact of structural or material changes with aging or disease on the frequency response of the PC.
A multiphysics model of the Pacinian corpuscle.
TLDR
This work combines mechanical models of the PC with an electrochemical model of peripheral nerves to simulate the tactile response of the entire system, and supports the hypothesis that PC rapid adaptation is affected by the lamellar structures without requiring neuronal adaptivity.
Micropipette aspiration of the Pacinian corpuscle.
An inter-species computational analysis of vibrotactile sensitivity in Pacinian and Herbst corpuscles
TLDR
This work applied an earlier computational model of the Pacinian corpuscle to predict the sensory response of different species to various stimulus frequencies, and based on the results, identified the optimal frequency for vibration sensing and the bandwidth over which frequencies should be most detectable.
Vibrotactile Sensitivity Threshold: Nonlinear Stochastic Mechanotransduction Model of the Pacinian Corpuscle
TLDR
A two-stage mechanotransduction model of its near threshold Vibrotactile (VT) sensitivity valid over 10 Hz to a few kHz is described and can be extended to simulate the neural response of a group of PCs.
Printing a Pacinian Corpuscle: Modeling and Performance
TLDR
A scalable mechanical model of the Pacinian corpuscle is developed and uses the model to predict the response of synthetic corpuscles, which could be the basis for future vibration sensors.
Computational Model of a Pacinian Corpuscle for an Electrical Stimulus: Spike-Rate and Threshold Characteristics
TLDR
A PC model with equivalent circuits of the electrode-skin interface, PC’s neurite, and the first Ranvier node is developed and can be extended to study the combination of electrical and mechanical stimuli.
Multiscale modeling methods in biomechanics
TLDR
A review of papers targeting the musculoskeletal and the cardiovascular systems, and covered only a few exemplary papers targeting other organ systems, shows a research subdomain still in its infancy, where causal confirmation papers remain the most common.
Layered patterns in nature, medicine and materials: quantification of anisotropic structures and cyclisity
TLDR
A parameter for structural disorder in a layered pattern (DStr) is presented to describe the deviation of a study object’s anisotropic structure from an isotropic analog and it is illustrated that charts and DStr could be used as local and global morphological characteristics describing various layered systems such as images of, for example, geological, atmospheric, medical, materials, forensic, plants, and animals.
Layered patterns in nature, medicine, and materials: quantifying anisotropic structures and cyclicity
TLDR
A parameter disorder of layer structure (DStr) is presented to describe the deviation of a study object’s anisotropic structure from an isotropic analog and it is illustrated that charts and DStr could be used as local and global morphological characteristics describing various layered systems such as images of, for example, geological, atmospheric, medical, materials, forensic, plants, and animals.
...
...

References

SHOWING 1-10 OF 44 REFERENCES
A biomechanical model of Pacinian Corpuscle & Skin
TLDR
A wide band biomechanical model of Pacinian Corpuscle (PC) embedded in skin and its response against the trapezoidal and sinusoidal stimuli is described in order to study human vibrotactile sensitivity near the VT Sensitivity Threshold.
Nonlinear two stage mechanotransduction model and neural response of Pacinian Corpuscle
TLDR
A biomechanical and neurophysiological model of skin and Pacinian Corpuscle (PC) to simulate its neural response over few 10s of Hz to 2000 Hz obtained from experiments to help in enhancing the technologies related to perception of vibration.
A model of a sensory mechanoreceptor derived from homogenization
A Pacinian corpuscle is a receptor that resides in the skin and other tissues and has the appearance of a bulb surrounding a nerve ending. Whenever a threshold stimulus is felt by the bulb, shear
A simple viscoelastic model for soft tissues the frequency range 6-20 MHz
  • Xinmai Yang, C. Church
  • Physics
    IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
  • 2006
TLDR
Measurements of the shear properties of porcine skeletal muscle, liver, and kidney and a novel model describing them are presented and a simple extension of the Voigt model is proposed to resolve the problem of negative storage moduli in traditional linear viscoelastic models.
The capsule structure of Pacinian corpuscles from the cat mesentery.
TLDR
The authors are of the opinion that the capsule and its lamellae have not only mechanical significance or the function of the transfer system and filter, but they form an important component (subsystem) of the whole metabolic system in the sensory corpuscle.
Vibrotactile Sensitivity Threshold: Nonlinear Stochastic Mechanotransduction Model of the Pacinian Corpuscle
TLDR
A two-stage mechanotransduction model of its near threshold Vibrotactile (VT) sensitivity valid over 10 Hz to a few kHz is described and can be extended to simulate the neural response of a group of PCs.
Viscoelastic properties of single attached cells under compression.
TLDR
The results are believed to reflect the viscoelastic mechanical behavior of cells, such as would be present in vivo, after a series of dynamic experiments over two frequency decades at a range of axial strains.
Visco-elastic properties of the rapidly adapting stretch receptor muscle of the crayfish.
TLDR
The results show that the rapidly adapting receptor muscle has a more pronounced dynamic component; the ratio between the amplitude of the peak and the steady state response was larger in the rapidly than in the slowly adapting receptor Muscle.
A re-evaluation of the cytology of cat Pacinian corpuscles
TLDR
The extreme tip of the axon of a Pacinian corpuscle has been identified and is quite different from the previously described ultraterminal region, and axonal spines at the cleft and extreme tip are proposed as a site of restricted current flow due to the tight apposition of inner core lamellae to the axolemma of X-axis.
...
...