Multiscale DNA partitioning: statistical evidence for segments

  title={Multiscale DNA partitioning: statistical evidence for segments},
  author={Andreas Futschik and Thomas Hotz and Axel Munk and Hannes Sieling},
  volume={30 16},
MOTIVATION DNA segmentation, i.e. the partitioning of DNA in compositionally homogeneous segments, is a basic task in bioinformatics. Different algorithms have been proposed for various partitioning criteria such as Guanine/Cytosine (GC) content, local ancestry in population genetics or copy number variation. A critical component of any such method is the choice of an appropriate number of segments. Some methods use model selection criteria and do not provide a suitable error control. Other… CONTINUE READING
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