Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.

@article{Harbst2016MultiregionWS,
  title={Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.},
  author={Katja Harbst and Martin Lauss and Helena M Cirenajwis and Karolin Isaksson and Frida Rosengren and Therese T{\"o}rngren and Anders Kvist and Maria C Johansson and Johan Vallon-Christersson and Bo Baldetorp and {\AA}ke Borg and H{\aa}kan Olsson and Christian Ingvar and Ana Suellen B Carneiro and G{\"o}ran B. J{\"o}nsson},
  journal={Cancer research},
  year={2016},
  volume={76 16},
  pages={4765-74}
}
Cancer genome sequencing has shed light on the underlying genetic aberrations that drive tumorigenesis. However, current sequencing-based strategies, which focus on a single tumor biopsy, fail to take into account intratumoral heterogeneity. To address this challenge and elucidate the evolutionary history of melanoma, we performed whole-exome and transcriptome sequencing of 41 multiple melanoma biopsies from eight individual tumors. This approach revealed heterogeneous somatic mutations in the… CONTINUE READING
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