Multipotential differentiation of human urine‐derived stem cells: Potential for therapeutic applications in urology

@article{Bharadwaj2013MultipotentialDO,
  title={Multipotential differentiation of human urine‐derived stem cells: Potential for therapeutic applications in urology},
  author={Shantaram Bharadwaj and Guihua Liu and Ying-ai Shi and Rongpei Wu and Bin Xia Yang and Tongchuan He and Yuxin Fan and Xinyan Lu and Xiaobo Zhou and Hong Liu and Anthony Atala and Jan Rohozinski and Yuanyuan Zhang},
  journal={STEM CELLS},
  year={2013},
  volume={31}
}
We sought to biologically characterize and identify a subpopulation of urine‐derived stem cells (USCs) with the capacity for multipotent differentiation. We demonstrated that single USCs can expand to a large population with 60–70 population doublings. Nine of 15 individual USC clones expressed detectable levels of telomerase and have long telomeres. These cells expressed pericyte and mesenchymal stem cell markers. Upon induction with appropriate media in vitro, USCs differentiated into bladder… 

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Generation of Mesenchymal-Like Stem Cells From Urine in Pediatric Patients.

Urine-derived stem cells for potential use in bladder repair

Urine-derived stem cells (USCs) provide advantages for cell therapy and tissue engineering applications in bladder tissue repair because they originate from the urinary tract system and can be obtained via a noninvasive, simple, and low-cost approach and induced with high efficiency to differentiate into bladder cells.
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