Multipotent stromal cells skew monocytes towards an anti-inflammatory function: the link with key immunoregulatory molecules.

@article{Melief2013MultipotentSC,
  title={Multipotent stromal cells skew monocytes towards an anti-inflammatory function: the link with key immunoregulatory molecules.},
  author={Sara M. Melief and Sacha Brigitte Geutskens and Willem E. Fibbe and Helene Roelofs},
  journal={Haematologica},
  year={2013},
  volume={98 9},
  pages={e121-2}
}
We thank Campioni et al. for their response to our recent publication in which they focus on the relevance of other molecules besides IL-6 and IL-10 for the immunomodulatory functions of multipotent stromal cells (MSC). In our publication, we had focused on the mechanistic roles for IL-6 and IL-10 in the immunosuppressive effects of MSC. However, we agree that other factors may be important as well. We discuss here how the various, sometimes paradoxical, observations can be combined into an… CONTINUE READING

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