Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6.

@article{Melief2013MultipotentSC,
  title={Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6.},
  author={Sara M. Melief and Sacha B. Geutskens and Willem E. Fibbe and Helene Roelofs},
  journal={Haematologica},
  year={2013},
  volume={98 6},
  pages={
          888-95
        }
}
Multipotent stromal cells have immunomodulatory capacities and have been used in transplantation and autoimmune diseases. One of the effects of multipotent stromal cells involves the inhibition of dendritic cell differentiation. Since interleukin-6 and interleukin-10 are known to play a role in inhibiting immature dendritic cell differentiation, we hypothesized that these cytokines may also mediate the inhibitory effect of human multipotent stromal cells in immature dendritic cell… CONTINUE READING

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