Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.

@article{Lee2006MultipotentSC,
  title={Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.},
  author={Ryang Hwa Lee and M. J. Seo and Roxanne L. Reger and Jeffrey L. Spees and Andrey A Pulin and Scott D Olson and D. J. Prockop},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 46},
  pages={17438-43}
}
We tested the hypothesis that multipotent stromal cells from human bone marrow (hMSCs) can provide a potential therapy for human diabetes mellitus. Severe but nonlethal hyperglycemia was produced in NOD/scid mice with daily low doses of streptozotocin on days 1-4, and hMSCs were delivered via intracardiac infusion on days 10 and 17. The hMSCs lowered blood glucose levels in the diabetic mice on day 32 relative to untreated controls (18.34 mM +/- 1.12 SE vs. 27.78 mM +/- 2.45 SE, P = 0.0019… CONTINUE READING