Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients.

@article{Cuneo1989MultipotentSC,
  title={Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients.},
  author={A. Cuneo and C. Mecucci and S. Kerim and E. Vandenberghe and P. Dal Cin and A. van Orshoven and J. Rodhain and A. Bosly and J. Michaux and P. Martiat},
  journal={Blood},
  year={1989},
  volume={74 5},
  pages={
          1781-90
        }
}
Cytologic and cytogenetic results obtained from patients fulfilling the FAB criteria for the diagnosis of acute nonlymphocytic leukemia (ANLL) of megakaryocytic lineage (ANLL-M7) are reported. Eleven cases were de novo ANLL-M7, of whom three presented with acute myelofibrosis. Four cases were megakaryoblastic transformations of chronic myelogenous leukemia (two cases), refractory anemia with excess of blasts (one case), and polycythemia vera (one case). Four patients showed a minority of… Expand
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