Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons.

@article{Moe2005MultipotentPC,
  title={Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons.},
  author={Morten C Moe and Mercy Varghese and Alexandre I Danilov and Ulf Westerlund and Jon Ramm-Pettersen and Lou Brundin and Mikael Svensson and Jon Berg-Johnsen and Iver Arne Langmoen},
  journal={Brain : a journal of neurology},
  year={2005},
  volume={128 Pt 9},
  pages={2189-99}
}
It was long held as an axiom that new neurons are not produced in the adult human brain. More recent studies have identified multipotent cells whose progeny express glial or neuronal markers. This discovery may lead to new therapeutic strategies for CNS disorders, either by stimulating neurogenesis in vivo or by transplanting multipotent progenitor cells (MPCs) that have been propagated and differentiated in vitro. The clinical application of such approaches will be limited by the ability of… CONTINUE READING

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