Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: development of a new minipig model.

@article{Agay2010MultipotentMS,
  title={Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: development of a new minipig model.},
  author={Diane Agay and Harry Scherthan and Fabien Forcheron and Nancy Grenier and Françis H{\'e}rodin and Viktor Meineke and Michel G. Drouet},
  journal={Experimental hematology},
  year={2010},
  volume={38 10},
  pages={
          945-56
        }
}
OBJECTIVE Cutaneous radiation syndrome (CRS) is the delayed consequence of localized skin exposure to high doses of ionizing radiation. Recent grafting of three ionizing radiation-burned patients has suggested the benefit of local bone marrow mesenchymal stem cell (MSC) injection in favor of wound healing and pain control. Here, we have developed a new minipig model of severe CRS to study underlying mechanisms of this cell therapy approach. MATERIALS AND METHODS Göttingen minipigs were… CONTINUE READING
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