Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment.

@article{Iso2007MultipotentHS,
  title={Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment.},
  author={Yoshitaka Iso and Jeffrey L. Spees and Claudia C Serrano and Benjamin Bakondi and Radhika R. Pochampally and Y Song and B. E. Sobel and Patrick Delafontaine and D. J. Prockop},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 3},
  pages={700-6}
}
The aim of this study was to determine whether intravenously administered multipotent stromal cells from human bone marrow (hMSCs) can improve cardiac function after myocardial infarction (MI) without long-term engraftment and therefore whether transitory paracrine effects or secreted factors are responsible for the benefit conferred. hMSCs were injected systemically into immunodeficient mice with acute MI. Cardiac function and fibrosis after MI in the hMSC-treated group were significantly… CONTINUE READING
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