Multipotent cells from mammalian iris pigment epithelium.

  title={Multipotent cells from mammalian iris pigment epithelium.},
  author={Maki Asami and Guangwei Sun and Masahiro Yamaguchi and Mitsuko Kosaka},
  journal={Developmental biology},
  volume={304 1},
The regeneration of lens tissue from the iris of newts has become a classical model of developmental plasticity, although little is known about the corresponding plasticity of the mammalian iris. We here demonstrate and characterize multipotent cells within the iris pigment epithelium (IPE) of postnatal and adult rodents. Acutely-isolated IPE cells were morphologically homogeneous and highly pigmented, but some produced neurospheres which expressed markers characteristic of neural stem… CONTINUE READING