Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules

@article{Dressel2009MultipotentAG,
  title={Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules},
  author={Ralf Dressel and Kaomei Guan and Jessica Nolte and Leslie Elsner and Sebastian Monecke and Karim Nayernia and Gerd Hasenfuss and Wolfgang Engel},
  journal={Biology Direct},
  year={2009},
  volume={4},
  pages={31 - 31}
}
Multipotent adult germ-line stem cells (maGSCs) represent a new pluripotent cell type that can be derived without genetic manipulation from spermatogonial stem cells (SSCs) present in adult testis. Similarly to induced pluripotent stem cells (iPSCs), they could provide a source of cellular grafts for new transplantation therapies of a broad variety of diseases. To test whether these stem cells can be rejected by the recipients, we have analyzed whether maGSCs and iPSCs can become targets for… CONTINUE READING