Multipoint linkage analysis using sib pairs: an interval mapping approach for dichotomous outcomes.

@article{Olson1995MultipointLA,
  title={Multipoint linkage analysis using sib pairs: an interval mapping approach for dichotomous outcomes.},
  author={Jane M. Olson},
  journal={American journal of human genetics},
  year={1995},
  volume={56 3},
  pages={788-98}
}
  • Jane M. Olson
  • Published 1995 in American journal of human genetics
I propose an interval mapping approach suitable for a dichotomous outcome, with emphasis on samples of affected sib pairs. The method computes a lod score for each of a set of locations in the interval between two flanking markers and takes as its estimate of trait-locus location the maximum lod score in the interval, provided it exceeds the prespecified critical value. Use of the method depends on prior knowledge of the genetic model for the disease only through available estimates of… CONTINUE READING

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