Multipoint approximations of identity-by-descent probabilities for accurate linkage analysis of distantly related individuals.


We propose an analytical approximation method for the estimation of multipoint identity by descent (IBD) probabilities in pedigrees containing a moderate number of distantly related individuals. We show that in large pedigrees where cases are related through untyped ancestors only, it is possible to formulate the hidden Markov model of the Lander-Green… (More)
DOI: 10.1016/j.ajhg.2007.12.016