Multiplicity reactivation of vaccinia virus particles treated with nitrogen mustard.

  title={Multiplicity reactivation of vaccinia virus particles treated with nitrogen mustard.},
  author={Kwang Sik Kim and Dr. J. G. Sharp},
  journal={Journal of virology},
  volume={1 1},
The nitrogen mustard bis(beta-chloroethyl)methylamine, a radiomimetic alkylating agent, is known for its ability to inactivate viruses in general and poxvirus in particular. These experiments show that vaccinia virus is rapidly inactivated by it. They show, in addition, that the treated virus exhibits multiplicity reactivation in L cells, closely resembling that experienced with the same virus after exposure to ultraviolet rays. These findings have come from observations of plaque titer, on the… CONTINUE READING
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