Multiplicity of hypoxia-inducible transcription factors and their connection to the circadian clock in the zebrafish.

Abstract

In zebrafish, as in most vertebrates, three different isoforms of the hypoxia-inducible transcription factor, Hif-1α, Hif-2α, and Hif-3α, have been identified. The expression data of genes encoding these three proteins, as analyzed so far, show distinct expression patterns for all three isoforms during early development, under hypoxic conditions, and during… (More)
DOI: 10.1086/679751

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