Multiplicity of eukaryotic ADH and other MDR forms.

  title={Multiplicity of eukaryotic ADH and other MDR forms.},
  author={Hans J{\"o}rnvall and Erik Nordling and Bengt Persson},
  journal={Chemico-biological interactions},
Eukaryotic genomes code for at least eight medium-chain dehydrogenases/reductases (MDR) enzyme families of two types, with and without Zn(2+) at the active site. Four families have Zn(2+): 'Dimeric alcohol dehydrogenases (ADHs)' (including liver ADHs), 'Tetrameric ADHs' (including the yeast ADHs), 'Cinnamyl ADHs' and 'Polyol DHs'. In the human genome, there are minimally 23 MDR genes, but the list is still growing from further interpretations. Of these, seven genes on chromosome 4 (and three… CONTINUE READING