Multiplicity of carbohydrate-binding sites in β-prism fold lectins: occurrence and possible evolutionary implications

@article{Sharma2007MultiplicityOC,
  title={Multiplicity of carbohydrate-binding sites in β-prism fold lectins: occurrence and possible evolutionary implications},
  author={Alok Kumar Sharma and Divya Chandran and Desh Singh and Mamannamana Vijayan},
  journal={Journal of Biosciences},
  year={2007},
  volume={32},
  pages={1089-1110}
}
The β-prism II fold lectins of known structure, all from monocots, invariably have three carbohydrate-binding sites in each subunit/domain. Until recently, β-prism I fold lectins of known structure were all from dicots and they exhibited one carbohydrate-binding site per subunit/domain. However, the recently determined structure of the β-prism fold I lectin from banana, a monocot, has two very similar carbohydrate-binding sites. This prompted a detailed analysis of all the sequences appropriate… CONTINUE READING