Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP)

@article{Nielsen2005MultiplicityIP,
  title={Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP)},
  author={Maartje Nielsen and Patrick F. Franken and Tjitske H. C. M. Reinards and Marjan M. Weiss and Anja Wagner and Heleen M. van der Klift and Sanne F Kloosterman and Jeanine J. Houwing-Duistermaat and Cora M Aalfs and Margreet G Ausems and Annette Br{\"o}cker-Vriends and Encarna B. G{\'o}mez Garc{\'i}a and Nicoline Hoogerbrugge and Fred H. Menko and Rolf H. Sijmons and Senno Verhoef and Ernst J. Kuipers and Hans Morreau and Martijn H. Breuning and Carli M.J. Tops and Juul Th. Wijnen and Hans F A Vasen and Riccardo Fodde and F. J. Hes},
  journal={Journal of Medical Genetics},
  year={2005},
  volume={42},
  pages={e54 - e54}
}
Objective: To investigate the contribution of MYH associated polyposis coli (MAP) among polyposis families in the Netherlands, and the prevalence of colonic and extracolonic manifestations in MAP patients. Methods: 170 patients with polyposis coli, who previously tested negative for APC mutations, were screened by denaturing gradient gel electrophoresis and direct sequencing to identify MYH germline mutations. Results: Homozygous and compound heterozygous MYH mutations were identified in 40… Expand
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