Multiplicity generates diversity in the retinoic acid signalling pathways.

  title={Multiplicity generates diversity in the retinoic acid signalling pathways.},
  author={Mark E Leid and Philippe Kastner and Pierre Chambon},
  journal={Trends in biochemical sciences},
  volume={17 10},
Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric interactions between two families of nuclear retinoic acid receptors, and between nuclear retinoic acid receptors and other members of the nuclear receptor superfamily. Thus, a complex array of… CONTINUE READING
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