Multiplexed single-molecule measurements with magnetic tweezers.

@article{Ribeck2008MultiplexedSM,
  title={Multiplexed single-molecule measurements with magnetic tweezers.},
  author={Noah Ribeck and Omar A Saleh},
  journal={The Review of scientific instruments},
  year={2008},
  volume={79 9},
  pages={
          094301
        }
}
We present a method for performing multiple single-molecule manipulation experiments in parallel with magnetic tweezers. We use a microscope with a low magnification, and thus a wide field of view, to visualize multiple DNA-tethered paramagnetic beads and apply an optimized image analysis routine to track the three-dimensional position of each bead simultaneously in real time. Force is applied to each bead using an externally applied magnetic field. Since variations in the field parameters are… CONTINUE READING

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