Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.

Abstract

As principal degrading enzymes of the extracellular matrix, metalloproteinases (MPs) contribute to various pathologies and represent a family of promising drug targets and biomarker candidates. However, multiple proteases and endogenous inhibitors interact to govern MP activity, often leading to highly context-dependent protease function that unfortunately… (More)
DOI: 10.1021/ja307866z

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