Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy.

@article{Zavaleta2009MultiplexedIO,
  title={Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy.},
  author={Cristina L. Zavaleta and Bryan R. Smith and Ian Walton and William E Doering and Glenn Davis and Borzoyeh Shojaei and Michael J. Natan and Sanjiv Sam Gambhir},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 32},
  pages={13511-6}
}
Raman spectroscopy is a newly developed, noninvasive preclinical imaging technique that offers picomolar sensitivity and multiplexing capabilities to the field of molecular imaging. In this study, we demonstrate the ability of Raman spectroscopy to separate the spectral fingerprints of up to 10 different types of surface enhanced Raman scattering (SERS) nanoparticles in a living mouse after s.c. injection. Based on these spectral results, we simultaneously injected the five most intense and… CONTINUE READING
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