Multiplexed electrical detection of cancer markers with nanowire sensor arrays

@article{Zheng2005MultiplexedED,
  title={Multiplexed electrical detection of cancer markers with nanowire sensor arrays},
  author={Gengfeng Zheng and Fernando Patolsky and Yi Cui and Wayne U. Wang and Charles M. Lieber},
  journal={Nature Biotechnology},
  year={2005},
  volume={23},
  pages={1294-1301}
}
We describe highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays. [] Key Result Protein markers were routinely detected at femtomolar concentrations with high selectivity, and simultaneous incorporation of control nanowires enabled discrimination against false positives.
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The electrical approach using the Si NW-ISFET platform shows a lower limit of detection and a wide dynamic range of the assay, and should be utilized to detect multiple biomarkers in one assay to obtain more reliable information about cancer-related diseases.
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The highly selective, simultaneous and multiplexed detection of PSA marker at attomolar concentrations, a level useful for clinical diagnosis of prostate cancer, was demonstrated and the detection ability was corroborated to be effective by comparing the detection results at different pH values.
Label-Free Multiplexed Electrical Detection of Cancer Markers on a Microchip Featuring an Integrated Fluidic Diode Nanopore Array.
TLDR
An integrated array of glass nanopores on a silicon microchip fabricated in a batch process through low-resolution photolithography and standard semiconductor processing tools is introduced and ultrasensitive, label-free, multiplexed electrical detection of cancer-marker proteins in real time through charge-dependent ionic current rectification is demonstrated.
Silicon nanowire biosensor for highly sensitive and multiplexed detection of oral squamous cell carcinoma biomarkers in saliva.
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A multiplexed detection methodology for IL-8 and TNF-α detection in saliva using SiNW FET biosensors is developed and is expected to be widely used for the early diagnosis of oral squamous cell carcinoma.
Nanotube-antibody biosensor arrays for the detection of circulating breast cancer cells.
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A nanoscale oncometer with single cell sensitivity with a diameter 1000 times smaller than a cancer cell that functions in a drop of fresh blood is reported, it appears that the binding of a single cell to a single nanotube field effect transistor produced the change in electrical conductivity.
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