Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy.

@article{Wulfkuhle2008MultiplexedCS,
  title={Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy.},
  author={Julia D. Wulfkuhle and Runa Speer and Mariaelena Pierobon and Julie Laird and Virginia Espina and Jianghong Deng and Enzo Mammano and Sherry X. Yang and Sandra M Swain and Donato Nitti and Laura Esserman and Claudio Belluco and Lance A. Liotta and Emanual F. Petricoin},
  journal={Journal of proteome research},
  year={2008},
  volume={7 4},
  pages={1508-17}
}
Phosphoprotein driven cellular signaling events represent most of the new molecular targets for cancer treatment. Application of reverse-phase protein microarray technology for the study of ongoing signaling activity within breast tumor specimens holds great potential for elucidating and profiling signaling activity in real-time for patient-tailored therapy. Analysis of laser capture microdissection primary human breast tumors and metastatic lesions reveals pathway specific profiles and a new… CONTINUE READING