Multiplexed and amplified electronic sensor for the detection of microRNAs from cancer cells.

@article{Yang2014MultiplexedAA,
  title={Multiplexed and amplified electronic sensor for the detection of microRNAs from cancer cells.},
  author={Cuiyun Yang and Baoting Dou and Kai Shi and Yaqin Chai and Yun Xiang and Ruo Yuan},
  journal={Analytical chemistry},
  year={2014},
  volume={86 23},
  pages={
          11913-8
        }
}
The detection of microRNA expression profiles plays an important role in early diagnosis of different cancers. On the basis of the employment of redox labels with distinct potential positions and duplex specific nuclease (DSN)-assisted target recycling signal amplifications, we have developed a multiplexed and convenient electronic sensor for highly sensitive detection of microRNA (miRNA)-141 and miRNA-21. The sensor is constructed by self-assembly of thiol-modified, redox species-labeled… CONTINUE READING
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