Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows.

@article{Schilling2015MultiplexedSH,
  title={Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows.},
  author={Birgit Schilling and Brendan Maclean and Jason M Held and Alexandria K. Sahu and Matthew J Rardin and Dylan J. Sorensen and Theodore W. Peters and Alan J Wolfe and Christie L. Hunter and Michael J. MacCoss and Bradford W. Gibson},
  journal={Analytical chemistry},
  year={2015},
  volume={87 20},
  pages={10222-9}
}
Recent advances in commercial mass spectrometers with higher resolving power and faster scanning capabilities have expanded their functionality beyond traditional data-dependent acquisition (DDA) to targeted proteomics with higher precision and multiplexing. Using an orthogonal quadrupole time-of flight (QqTOF) LC-MS system, we investigated the feasibility of implementing large-scale targeted quantitative assays using scheduled, high resolution multiple reaction monitoring (sMRM-HR), also… CONTINUE READING
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