Multiplex relative risk and estimation of the number of loci underlying an inherited disease.

@article{Schliekelman2002MultiplexRR,
  title={Multiplex relative risk and estimation of the number of loci underlying an inherited disease.},
  author={Paul Schliekelman and Montgomery Slatkin},
  journal={American journal of human genetics},
  year={2002},
  volume={71 6},
  pages={1369-85}
}
Knowledge of the number of causative loci is necessary to estimate the power of mapping studies of complex diseases. In the present article, we reexamine a theory developed by Risch and its implications for estimating the number L of causative loci affecting a complex inherited disease. We first show that methods based on Risch's analysis can produce estimates of L that are inconsistent with the observed population prevalence of the disease. We demonstrate this point by showing that the maximum… CONTINUE READING

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Multiplex Relative Risk and Locus Number 1385 age is hard to find

  • JC Bear
  • 1976
Highly Influential
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