Multiplex ligation-dependent probe amplification versus multiprobe fluorescence in situ hybridization to detect genomic aberrations in chronic lymphocytic leukemia: a tertiary center experience.

@article{Zaabi2010MultiplexLP,
  title={Multiplex ligation-dependent probe amplification versus multiprobe fluorescence in situ hybridization to detect genomic aberrations in chronic lymphocytic leukemia: a tertiary center experience.},
  author={Eiman A Al Zaabi and Louis A V Fernandez and Irene A Sadek and D Christie Riddell and Wenda L. Greer},
  journal={The Journal of molecular diagnostics : JMD},
  year={2010},
  volume={12 2},
  pages={
          197-203
        }
}
Cytogenetic abnormalities play a major role in the prognosis of patients with chronic lymphocytic leukemia (CLL). Several methods have emerged to try to best identify these abnormalities. We used fluorescence in situ hybridization (FISH) to determine the frequency of cytogenetic changes in our CLL patient population. We also evaluated the effectiveness of multiplex ligation-dependent probe amplification (MLPA) in detecting these abnormalities. Sixty-two B-CLL patients and 20 healthy controls… CONTINUE READING

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