Multiplex ligation-dependent probe amplification (MLPA) genotyping assay for mouse models of down syndrome.

Abstract

The Ts65Dn mouse is the most widely investigated segmentally trisomic mouse model of Down syndrome. Quantitative PCR based methods are the preferred way of detecting the trisomic segment for genotyping purposes. However, identification of a 1.5 fold difference in target DNA is at the limit of detection of most quantitative PCR based methods, and in practice… (More)

Cite this paper

@article{Hewitt2007MultiplexLP, title={Multiplex ligation-dependent probe amplification (MLPA) genotyping assay for mouse models of down syndrome.}, author={Chelsee Ann Hewitt and Catherine Louise Carmichael and Ella Jane Wilkins and Ping Zhi Fang Cannon and M. Pritchard and Hamish S. Scott}, journal={Frontiers in bioscience : a journal and virtual library}, year={2007}, volume={12}, pages={3010-6} }