Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.

@article{Downing1995MultiplexRA,
  title={Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.},
  author={James R. Downing and Aamod Khandekar and Sheila Shurtleff and David R. Head and David M. Parham and Bruce L. Webber and Alberto S. Pappo and M G Hulshof and W P Conn and David N. Shapiro},
  journal={The American journal of pathology},
  year={1995},
  volume={146 3},
  pages={626-34}
}
Cytogenetic analysis has defined specific translocations associated with two of the most common small round cell tumors of childhood, t(11;22) in Ewing's sarcoma and t(2;13) in alveolar rhabdomyosarcoma. We and others have previously demonstrated the diagnostic utility of a reverse transcriptase polymerase chain reaction (RT-PCR) assay for the detection of the t(11;22) encoded EWS/FLI-1 chimeric message in Ewing's sarcoma. More recently, we have cloned the t(2;13)(q35;q14) translocation and… CONTINUE READING

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