Multiplex PCR screening detects small p53 deletions and insertions in human ovarian cancer cell lines

@article{Runnebaum1994MultiplexPS,
  title={Multiplex PCR screening detects small p53 deletions and insertions in human ovarian cancer cell lines},
  author={I B Runnebaum and Xiao-wen Tong and Volker J Moebus and Volker Heilmann and Dirk G{\"u}nter Kieback and Rolf Kreienberg},
  journal={Human Genetics},
  year={1994},
  volume={93},
  pages={620-624}
}
Mutations at the p53 tumor suppressor gene locus are a frequent genetic alteration associated with human ovarian carcinoma. Little information exists regarding whether mutational events occur other than point mutations and large deletions, causing loss of heterozygosity. Small intragenic deletions and insertions in the p53 gene have been observed in various human neoplasias. We developed a multiplex polymerase chain reaction (MPCR) screening assay to amplify the complete p53 coding region from… CONTINUE READING

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p53 gene mutations and protein accumulation in human ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America • 1993
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