Multiple ways to switch platelet integrins on and off.

  title={Multiple ways to switch platelet integrins on and off.},
  author={Judith M E M Cosemans and Brecht F Iserbyt and Hans Deckmyn and Johan W. M. Heemskerk},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={6 8},
In the classical concept of platelet integrin activation, it is considered that unidirectional conformational changes of alpha(IIb)beta(3) and alpha(2)beta(1) regulate the adhesiveness of platelets for fibrin(ogen) and collagen, respectively. Here, we summarize recent evidence that these conformational changes: (i) can also occur in the reverse direction; and (ii) are not independent events. Platelet stimulation through the P2Y(12) receptors provokes only transient alpha(IIb)beta(3) activation… CONTINUE READING

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