Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons.

  title={Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons.},
  author={Ege T Kavalali and Mark R. Plummer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={16 3},
Neuronal voltage-gated calcium channels provide a pathway for calcium influx that is required for processes ranging from intracellular signaling to alterations in cellular excitability. In hippocampal neurons, we have characterized a subtype of dihydropyridine-sensitive L-type calcium channels (Lp channel) that shows multiple kinds of voltage-dependent potentiation of its activity. One type of potentiation is elicited by low-voltage stimuli (-10 mV) and can be seen in dual-pulse protocols in… CONTINUE READING
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