Multiple variants in subtelomeric regions of normal karyotypes.

  title={Multiple variants in subtelomeric regions of normal karyotypes.},
  author={Jacob W. Ijdo and Elizabeth A. Lindsay and Robert A Wells and Antonio Baldini},
  volume={14 4},
We describe a human genomic cosmid clone, 56.1.1, that contains subtelomeric sequences present on multiple human chromosomes. In particular, using fluorescence in situ hybridization, we have identified 16 sites of hybridization on 12 chromosomes. In a sample of 8 unrelated individuals, 10 of these sites showed interindividual variation. Co-hybridization with other polymorphic probes allowed us to demonstrate cytologically heterozygosity at three sites in six individuals. The chromosomal… CONTINUE READING