Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.

@article{Lecker2004MultipleTO,
  title={Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression.},
  author={Stewart H. Lecker and R Thomas Jagoe and Alexander Gilbert and Marcelo Gomes de Gomes and Vickie Baracos and J. Bailey and Stephen R. Price and William E. Mitch and Alfred L Goldberg},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 1},
  pages={39-51}
}
Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases including diabetes, cancer, and renal failure. We had proposed that a common set of transcriptional adaptations underlie the loss of muscle mass in these different states. To test this hypothesis, we used cDNA microarrays to compare the changes in content of specific mRNAs in muscles atrophying from different causes. We compared muscles from fasted mice, from rats with cancer cachexia, streptozotocin… CONTINUE READING
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