Multiple transcription factor elements collaborate with estrogen receptor alpha to activate an inducible estrogen response element in the NKG2E gene.

@article{Levy2007MultipleTF,
  title={Multiple transcription factor elements collaborate with estrogen receptor alpha to activate an inducible estrogen response element in the NKG2E gene.},
  author={Nitzan Levy and Xiaoyue Zhao and Hui Tang and Robert B. Jaffe and Terence P. Speed and Dale C. Leitman},
  journal={Endocrinology},
  year={2007},
  volume={148 7},
  pages={3449-58}
}
Estrogen receptors (ERs) regulate transcription by interacting with regulatory elements in target genes. However, known ER regulatory elements cannot explain the expression profiles of genes activated by estradiol (E2) and selective estrogen receptor modulators (SERMs). We previously showed that the killer cell lectin-like receptor (NKG2E) gene is regulated by E2, tamoxifen, and raloxifene. Here we used the NKG2E gene as a model to investigate the mechanism whereby target genes are regulated by… CONTINUE READING
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