Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.

@article{Jaeger2004MultipleTR,
  title={Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.},
  author={Timo Jaeger and Heike Budde and Leopold Floh{\'e} and Ulrich Menge and Mahavir Singh and Madia Trujillo and Rafael Radi},
  journal={Archives of biochemistry and biophysics},
  year={2004},
  volume={423 1},
  pages={182-91}
}
Drug resistance and virulence of Mycobacterium tuberculosis are in part related to the pathogen's antioxidant defense systems. KatG(-) strains are resistant to the first line tuberculostatic isoniazid but need to compensate their catalase deficiency by alternative peroxidase systems to stay virulent. So far, only NADH-driven and AhpD-mediated hydroperoxide reduction by AhpC has been implicated as such virulence-determining mechanism. We here report on two novel pathways which underscore the… CONTINUE READING

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