Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells

@article{Subramanyam2011MultipleTO,
  title={Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells},
  author={Deepa Subramanyam and Samy Lamouille and Robert L Judson and Jason Yingjie Liu and Nathan Bucay and Rik Derynck and Robert Blelloch},
  journal={Nature Biotechnology},
  year={2011},
  volume={29},
  pages={443-448}
}
The embryonic stem cell–specific cell cycle–regulating (ESCC) family of microRNAs (miRNAs) enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. Here we show that the human ESCC miRNA orthologs hsa-miR-302b and hsa-miR-372 promote human somatic cell reprogramming. Furthermore, these miRNAs repress multiple target genes, with downregulation of individual targets only partially recapitulating the total miRNA effects. These targets regulate various cellular… CONTINUE READING
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