Multiple targets of chemosensitive signaling in locus coeruleus neurons: role of K+ and Ca2+ channels.

@article{Filosa2003MultipleTO,
  title={Multiple targets of chemosensitive signaling in locus coeruleus neurons: role of K+ and Ca2+ channels.},
  author={Jessica A Filosa and Robert W. Putnam},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={284 1},
  pages={
          C145-55
        }
}
We studied chemosensitive signaling in locus coeruleus (LC) neurons using both perforated and whole cell patch techniques. Upon inhibition of fast Na(+) spikes by tetrodotoxin (TTX), hypercapnic acidosis [HA; 15% CO(2), extracellular pH (pH(o)) 6.8] induced small, slow spikes. These spikes were inhibited by Co(2+) or nifedipine and were attributed to activation of L-type Ca(2+) channels by HA. Upon inhibition of both Na(+) and Ca(2+) spikes, HA resulted in a membrane depolarization of 3.52… CONTINUE READING

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