Multiple system atrophy

@article{Wenning2004MultipleSA,
  title={Multiple system atrophy},
  author={Gregor K. Wenning and Carlo Colosimo and Felix Geser and Werner Poewe},
  journal={The Lancet Neurology},
  year={2004},
  volume={3},
  pages={93-103}
}
Multiple system atrophy (MSA) is an adult-onset sporadic progressive neurodegenerative disorder of unknown etiology. It is clinically characterized by the variable combination of autonomic failure, parkinsonism, cerebellar ataxia, and pyramidal signs. The present review summarizes up-to-date knowledge on the clinical diagnosis and molecular pathology of MSA. We also review the role of additional investigations that may support a clinical diagnosis of MSA. Finally, we briefly discuss the… 
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The clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction, are described and criteria to define the relative importance of these features are set.
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TLDR
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TLDR
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TLDR
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