Multiple system atrophy: pathogenic mechanisms and biomarkers

@article{Jellinger2016MultipleSA,
  title={Multiple system atrophy: pathogenic mechanisms and biomarkers},
  author={Kurt A. Jellinger and Gregor K. Wenning},
  journal={Journal of Neural Transmission},
  year={2016},
  volume={123},
  pages={555-572}
}
Multiple system atrophy (MSA) is a unique proteinopathy that differs from other α-synucleinopathies since the pathological process resulting from accumulation of aberrant α-synuclein (αSyn) involves the oligodendroglia rather than neurons, although both pathologies affect multiple parts of the brain, spinal cord, autonomic and peripheral nervous system. Both the etiology and pathogenesis of MSA are unknown, although animal models have provided insight into the basic molecular changes of this… CONTINUE READING
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