Multiple switches in G protein-coupled receptor activation.

  title={Multiple switches in G protein-coupled receptor activation.},
  author={Shivani Ahuja and Steven Oliver Smith},
  journal={Trends in pharmacological sciences},
  volume={30 9},
The activation mechanism of G protein-coupled receptors has presented a puzzle that finally may be close to solution. These receptors have a relatively simple architecture consisting of seven transmembrane helices that contain just a handful of highly conserved amino acids, yet they respond to light and a range of chemically diverse ligands. Recent NMR structural studies on the active metarhodopsin II intermediate of the visual receptor rhodopsin, along with the recent crystal structure of the… CONTINUE READING

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