Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study.

@article{AlKateb2008MultipleSD,
  title={Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study.},
  author={Hussam Al-Kateb and Andrew P. Boright and Lucia Mirea and Xinlei Xie and Rinku Sutradhar and Alireza Mowjoodi and Bhupinder Bharaj and Michelle Liu and Jean M Bucksa and Valerie L. Arends and Michael W. Steffes and Patricia A. Cleary and Wanjie Sun and John M Lachin and Paul Scott Thorner and Michael Ho and Amy-Jayne McKnight and Alexander Peter Maxwell and David A. Savage and Kenneth K. Kidd and Judith R. Kidd and William C. Speed and Trevor John Orchard and Rachel G Miller and Lei Sun and Shelley B. Bull and Andrew D Paterson},
  journal={Diabetes},
  year={2008},
  volume={57 1},
  pages={218-28}
}
BACKGROUND Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes. RESEARCH DESIGN AND METHODS We performed an individual-based genetic association study with time to renal and retinal outcomes in 1,362 white probands with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Specifically, we genotyped… CONTINUE READING

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