Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.

@article{Akao1994MultipleSL,
  title={Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.},
  author={Yukihiro Akao and Yoshinori Otsuki and Sayo Kataoka and Yoshiaki Ito and Yoshihide Tsujimoto},
  journal={Cancer research},
  year={1994},
  volume={54 9},
  pages={2468-71}
}
The use of biochemical fractionation, immunofluorescence laser-scanning confocal microscopy, and immunoelectron microscopy with mouse anti-human bcl-2 monoclonal antibody to analyze the subcellular localization of the bcl-2 gene product revealed the protein prominently in the nuclear envelope, endoplasmic reticulum membrane, and mitochondrial membranes. Electron microscopy at high magnification more precisely localized bcl-2 to the nuclear outer membrane as confirmed by the biochemical… CONTINUE READING

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