Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.

@article{Larsson1998MultipleSV,
  title={Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.},
  author={Petra K Larsson and H E Cla{\'e}sson and Brian P. Kennedy},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 1},
  pages={207-14}
}
Recently, the cloning of a novel Ca2+-independent phospholipase A2 (iPLA2) from Chinese hamster ovary cells as well as from mouse and rat sources containing a C-terminal lipase motif and eight N-terminal ankyrin repeats has been described. In this report we describe the cloning of the human iPLA2 cDNA and its expression in B-cells and show that the iPLA2 gene undergoes extensive alternative splicing generating multiple isoforms that contribute to a novel mechanism to control iPLA2 activity. The… CONTINUE READING

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