Multiple splenic lymphoid cell subpopulations regulate H-2 antigen expression on teratocarcinoma cells in vivo.

@article{OstrandRosenberg1983MultipleSL,
  title={Multiple splenic lymphoid cell subpopulations regulate H-2 antigen expression on teratocarcinoma cells in vivo.},
  author={Suzanne Ostrand-Rosenberg and Allen Lee Cohn and Jean-Paul Sandoz},
  journal={Journal of immunology},
  year={1983},
  volume={130 6},
  pages={2969-73}
}
Undifferentiated murine 402AX teratocarcinoma cells do not express MHC antigens when passaged in vitro or in vivo in genetically susceptible host mice. When passaged in vivo in genetically resistant mice, however, the tumor cells become H-2b antigen positive regardless of the H-2 haplotype of the resistant host mouse. The present studies use monoclonal anti-H-2b antibodies to corroborate these earlier findings, which were performed with conventional antisera. Previous studies have established… CONTINUE READING